<?xml version="1.0" encoding="UTF-8"?>

<!-- This model was downloaded from BioModels Database -->
<!-- Mon Mar 28 12:25:33 BST 2011                      -->
<!-- http://www.ebi.ac.uk/biomodels/                   -->

<sbml xmlns="http://www.sbml.org/sbml/level2/version4" metaid="metaid_0000001" level="2" version="4">
  <model metaid="metaid_0000002" id="Model_0" name="Goldbeter2006_weightCycling">
    <notes>
      <p xmlns="http://www.w3.org/1999/xhtml">This model is according to the paper of <i>A model for the dynamics of human weight cycling</i> by A. Goldbeter 2006.The figure3 (A) and (B) have been reproduced by Copasi 4.0.19(development) and SBMLodeSolver.The writer of the paper did not specify any units for the metabolites, so the creator of the model did not define the units as well.Both Q and R are normalized to vary between 0 and 1.</p>
      <p xmlns="http://www.w3.org/1999/xhtml">This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2010 The BioModels.net Team.<br/>For more information see the <a href="http://www.ebi.ac.uk/biomodels/legal.html" target="_blank">terms of use</a>.<br/>To cite BioModels Database, please use: <a href="http://www.ncbi.nlm.nih.gov/pubmed/20587024" target="_blank">Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.</a>
    </p>
  </notes>
  <annotation>
    <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
      <rdf:Description rdf:about="#metaid_0000002">
        <dc:creator>
          <rdf:Bag>
            <rdf:li rdf:parseType="Resource">
              <vCard:N rdf:parseType="Resource">
                <vCard:Family>He</vCard:Family>
                <vCard:Given>Enuo</vCard:Given>
              </vCard:N>
              <vCard:EMAIL>enuo@ebi.ac.uk</vCard:EMAIL>
              <vCard:ORG rdf:parseType="Resource">
                <vCard:Orgname>EMBL-EBI</vCard:Orgname>
              </vCard:ORG>
            </rdf:li>
          </rdf:Bag>
        </dc:creator>
        <dcterms:created rdf:parseType="Resource">
          <dcterms:W3CDTF>2006-11-24T10:19:23Z</dcterms:W3CDTF>
        </dcterms:created>
        <dcterms:modified rdf:parseType="Resource">
          <dcterms:W3CDTF>2010-01-18T11:34:42Z</dcterms:W3CDTF>
        </dcterms:modified>
        <bqmodel:is>
          <rdf:Bag>
            <rdf:li rdf:resource="urn:miriam:biomodels.db:BIOMD0000000079"/>
          </rdf:Bag>
        </bqmodel:is>
        <bqmodel:is>
          <rdf:Bag>
            <rdf:li rdf:resource="urn:miriam:biomodels.db:MODEL4644593552"/>
          </rdf:Bag>
        </bqmodel:is>
        <bqmodel:isDescribedBy>
          <rdf:Bag>
            <rdf:li rdf:resource="urn:miriam:pubmed:16595882"/>
          </rdf:Bag>
        </bqmodel:isDescribedBy>
        <bqbiol:isVersionOf>
          <rdf:Bag>
            <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0048511"/>
          </rdf:Bag>
        </bqbiol:isVersionOf>
        <bqbiol:isVersionOf>
          <rdf:Bag>
            <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0040014"/>
          </rdf:Bag>
        </bqbiol:isVersionOf>
      </rdf:Description>
    </rdf:RDF>
  </annotation>
  <listOfFunctionDefinitions>
    <functionDefinition metaid="metaid_0000003" id="function_4">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <lambda>
          <bvar>
            <ci> P </ci>
          </bvar>
          <bvar>
            <ci> V3 </ci>
          </bvar>
          <bvar>
            <ci> R </ci>
          </bvar>
          <bvar>
            <ci> k3 </ci>
          </bvar>
          <apply>
            <divide/>
            <apply>
              <times/>
              <ci> P </ci>
              <ci> V3 </ci>
              <apply>
                <minus/>
                <cn> 1 </cn>
                <ci> R </ci>
              </apply>
            </apply>
            <apply>
              <plus/>
              <ci> k3 </ci>
              <apply>
                <minus/>
                <cn> 1 </cn>
                <ci> R </ci>
              </apply>
            </apply>
          </apply>
        </lambda>
      </math>
    </functionDefinition>
    <functionDefinition metaid="metaid_0000004" id="function_3">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <lambda>
          <bvar>
            <ci> V2 </ci>
          </bvar>
          <bvar>
            <ci> R </ci>
          </bvar>
          <bvar>
            <ci> Q </ci>
          </bvar>
          <bvar>
            <ci> K2 </ci>
          </bvar>
          <apply>
            <divide/>
            <apply>
              <times/>
              <ci> V2 </ci>
              <ci> R </ci>
              <ci> Q </ci>
            </apply>
            <apply>
              <plus/>
              <ci> K2 </ci>
              <ci> Q </ci>
            </apply>
          </apply>
        </lambda>
      </math>
    </functionDefinition>
    <functionDefinition metaid="metaid_0000005" id="function_2">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <lambda>
          <bvar>
            <ci> V1 </ci>
          </bvar>
          <bvar>
            <ci> Q </ci>
          </bvar>
          <bvar>
            <ci> K1 </ci>
          </bvar>
          <apply>
            <divide/>
            <apply>
              <times/>
              <ci> V1 </ci>
              <apply>
                <minus/>
                <cn> 1 </cn>
                <ci> Q </ci>
              </apply>
            </apply>
            <apply>
              <plus/>
              <ci> K1 </ci>
              <apply>
                <minus/>
                <cn> 1 </cn>
                <ci> Q </ci>
              </apply>
            </apply>
          </apply>
        </lambda>
      </math>
    </functionDefinition>
    <functionDefinition metaid="metaid_0000006" id="function_1">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <lambda>
          <bvar>
            <ci> V </ci>
          </bvar>
          <bvar>
            <ci> substrate </ci>
          </bvar>
          <bvar>
            <ci> Km </ci>
          </bvar>
          <apply>
            <divide/>
            <apply>
              <times/>
              <ci> V </ci>
              <ci> substrate </ci>
            </apply>
            <apply>
              <plus/>
              <ci> Km </ci>
              <ci> substrate </ci>
            </apply>
          </apply>
        </lambda>
      </math>
    </functionDefinition>
    <functionDefinition metaid="metaid_0000007" id="function_0">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <lambda>
          <bvar>
            <ci> a </ci>
          </bvar>
          <bvar>
            <ci> Q </ci>
          </bvar>
          <apply>
            <times/>
            <ci> a </ci>
            <ci> Q </ci>
          </apply>
        </lambda>
      </math>
    </functionDefinition>
  </listOfFunctionDefinitions>
  <listOfUnitDefinitions>
    <unitDefinition metaid="metaid_0000021" id="time" name="weeks">
      <listOfUnits>
        <unit kind="second" multiplier="604800"/>
      </listOfUnits>
    </unitDefinition>
    <unitDefinition metaid="metaid_0000022" id="substance" name="dimensionless">
      <listOfUnits>
        <unit kind="dimensionless"/>
      </listOfUnits>
    </unitDefinition>
  </listOfUnitDefinitions>
  <listOfCompartments>
    <compartment metaid="metaid_0000011" id="body" name="body" size="1"/>
  </listOfCompartments>
  <listOfSpecies>
    <species metaid="metaid_0000012" id="P" name="P" compartment="body" initialConcentration="0.43" hasOnlySubstanceUnits="true">
      <notes>
        <p xmlns="http://www.w3.org/1999/xhtml">body weight</p>
      </notes>
    </species>
    <species metaid="metaid_0000013" id="Q" name="Q" compartment="body" initialConcentration="0.8" hasOnlySubstanceUnits="true">
      <notes>
        <p xmlns="http://www.w3.org/1999/xhtml">dietary intake</p>
      </notes>
    </species>
    <species metaid="metaid_0000014" id="R" name="R" compartment="body" initialConcentration="0.55" hasOnlySubstanceUnits="true">
      <notes>
        <p xmlns="http://www.w3.org/1999/xhtml">degree of resolution measuring cognitive restraint</p>
      </notes>
    </species>
  </listOfSpecies>
  <listOfReactions>
    <reaction metaid="metaid_0000015" id="reaction_0" name="Increase of  P" reversible="false">
      <annotation>
        <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
          <rdf:Description rdf:about="#metaid_0000015">
            <bqbiol:isVersionOf>
              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0035264"/>
                <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0040018"/>
              </rdf:Bag>
            </bqbiol:isVersionOf>
          </rdf:Description>
        </rdf:RDF>
      </annotation>
      <listOfProducts>
        <speciesReference species="P"/>
      </listOfProducts>
      <listOfModifiers>
        <modifierSpeciesReference species="Q"/>
      </listOfModifiers>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> body </ci>
            <apply>
              <ci> function_0 </ci>
              <ci> a </ci>
              <ci> Q </ci>
            </apply>
          </apply>
        </math>
        <listOfParameters>
          <parameter metaid="_462950" id="a" value="0.1"/>
        </listOfParameters>
      </kineticLaw>
    </reaction>
    <reaction metaid="metaid_0000016" id="reaction_1" name="Decrease of P" reversible="false">
      <annotation>
        <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
          <rdf:Description rdf:about="#metaid_0000016">
            <bqbiol:isVersionOf>
              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0040015"/>
              </rdf:Bag>
            </bqbiol:isVersionOf>
          </rdf:Description>
        </rdf:RDF>
      </annotation>
      <listOfReactants>
        <speciesReference species="P"/>
      </listOfReactants>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <ci> function_1 </ci>
            <ci> V </ci>
            <ci> P </ci>
            <ci> Km </ci>
          </apply>
        </math>
        <listOfParameters>
          <parameter metaid="_462951" id="V" value="0.1"/>
          <parameter metaid="_462952" id="Km" value="0.2"/>
        </listOfParameters>
      </kineticLaw>
    </reaction>
    <reaction metaid="metaid_0000017" id="reaction_2" name="Increase of Q" reversible="false">
      <annotation>
        <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
          <rdf:Description rdf:about="#metaid_0000017">
            <bqbiol:isVersionOf>
              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0007631"/>
              </rdf:Bag>
            </bqbiol:isVersionOf>
          </rdf:Description>
        </rdf:RDF>
      </annotation>
      <listOfProducts>
        <speciesReference species="Q"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <ci> function_2 </ci>
            <ci> V1 </ci>
            <ci> Q </ci>
            <ci> K1 </ci>
          </apply>
        </math>
        <listOfParameters>
          <parameter metaid="_462954" id="V1" value="1"/>
          <parameter metaid="_462957" id="K1" value="0.01"/>
        </listOfParameters>
      </kineticLaw>
    </reaction>
    <reaction metaid="metaid_0000018" id="reaction_3" name="Decrease of Q" reversible="false">
      <annotation>
        <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
          <rdf:Description rdf:about="#metaid_0000018">
            <bqbiol:isVersionOf>
              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0002023"/>
              </rdf:Bag>
            </bqbiol:isVersionOf>
          </rdf:Description>
        </rdf:RDF>
      </annotation>
      <listOfReactants>
        <speciesReference species="Q"/>
      </listOfReactants>
      <listOfModifiers>
        <modifierSpeciesReference species="R"/>
      </listOfModifiers>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <ci> function_3 </ci>
            <ci> V2 </ci>
            <ci> R </ci>
            <ci> Q </ci>
            <ci> K2 </ci>
          </apply>
        </math>
        <listOfParameters>
          <parameter metaid="_462959" id="V2" value="1.5"/>
          <parameter metaid="_462962" id="K2" value="0.01"/>
        </listOfParameters>
      </kineticLaw>
    </reaction>
    <reaction metaid="metaid_0000019" id="reaction_4" name="Increase of R" reversible="false">
      <annotation>
        <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
          <rdf:Description rdf:about="#metaid_0000019">
            <bqbiol:isVersionOf>
              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0048520"/>
              </rdf:Bag>
            </bqbiol:isVersionOf>
          </rdf:Description>
        </rdf:RDF>
      </annotation>
      <listOfProducts>
        <speciesReference species="R"/>
      </listOfProducts>
      <listOfModifiers>
        <modifierSpeciesReference species="P"/>
      </listOfModifiers>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <ci> function_4 </ci>
            <ci> P </ci>
            <ci> V3 </ci>
            <ci> R </ci>
            <ci> k3 </ci>
          </apply>
        </math>
        <listOfParameters>
          <parameter metaid="_462963" id="V3" value="6"/>
          <parameter metaid="_462964" id="k3" value="0.01"/>
        </listOfParameters>
      </kineticLaw>
    </reaction>
    <reaction metaid="metaid_0000020" id="reaction_5" name="Decrease of R" reversible="false">
      <annotation>
        <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
          <rdf:Description rdf:about="#metaid_0000020">
            <bqbiol:isVersionOf>
              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0048521"/>
              </rdf:Bag>
            </bqbiol:isVersionOf>
          </rdf:Description>
        </rdf:RDF>
      </annotation>
      <listOfReactants>
        <speciesReference species="R"/>
      </listOfReactants>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <ci> function_1 </ci>
            <ci> V </ci>
            <ci> R </ci>
            <ci> Km </ci>
          </apply>
        </math>
        <listOfParameters>
          <parameter metaid="_462965" id="V" value="2.5"/>
          <parameter metaid="_462966" id="Km" value="0.01"/>
        </listOfParameters>
      </kineticLaw>
    </reaction>
  </listOfReactions>
</model>
</sbml>
