4.0 SQUARE inactive active inactive inactive active inactive inactive active uVol inside PROTEIN pr1 inside PROTEIN pr2 inside PROTEIN pr3 inside PROTEIN pr2 inside PROTEIN pr1 inside PROTEIN pr1 inside PROTEIN pr3 inside PROTEIN pr3 J0 STATE_TRANSITION a0 a1 a7 $\frac{\mathrm{V1}\mathrm{MKKK}}{(1+\left(\frac{\mathrm{MAPK\_PP}}{\mathrm{Ki}}\right)^n)(\mathrm{K1}+\mathrm{MKKK})}$ J1 STATE_TRANSITION a1 a0 $\frac{\mathrm{V2}\mathrm{MKKK\_P}}{\mathrm{KK2}+\mathrm{MKKK\_P}}$ J2 STATE_TRANSITION a2 a3 a1 $\frac{\mathrm{k3}\mathrm{MKKK\_P}\mathrm{MKK}}{\mathrm{KK3}+\mathrm{MKK}}$ J3 STATE_TRANSITION a3 a4 a1 $\frac{\mathrm{k4}\mathrm{MKKK\_P}\mathrm{MKK\_P}}{\mathrm{KK4}+\mathrm{MKK\_P}}$ J4 STATE_TRANSITION a4 a3 $\frac{\mathrm{V5}\mathrm{MKK\_PP}}{\mathrm{KK5}+\mathrm{MKK\_PP}}$ J5 STATE_TRANSITION a3 a2 $\frac{\mathrm{V6}\mathrm{MKK\_P}}{\mathrm{KK6}+\mathrm{MKK\_P}}$ J6 STATE_TRANSITION a5 a6 a4 $\frac{\mathrm{k7}\mathrm{MKK\_PP}\mathrm{MAPK}}{\mathrm{KK7}+\mathrm{MAPK}}$ J7 STATE_TRANSITION a6 a7 a4 $\frac{\mathrm{k8}\mathrm{MKK\_PP}\mathrm{MAPK\_P}}{\mathrm{KK8}+\mathrm{MAPK\_P}}$ J8 STATE_TRANSITION a7 a6 $\frac{\mathrm{V9}\mathrm{MAPK\_PP}}{\mathrm{KK9}+\mathrm{MAPK\_PP}}$ J9 STATE_TRANSITION a6 a5 $\frac{\mathrm{V10}\mathrm{MAPK\_P}}{\mathrm{KK10}+\mathrm{MAPK\_P}}$