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<apply>
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          <speciesReference species="Source">
            <annotation>
              <celldesigner:alias>sa4</celldesigner:alias>
            </annotation>
          </speciesReference>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="m_tetR">
            <annotation>
              <celldesigner:alias>sa5</celldesigner:alias>
            </annotation>
          </speciesReference>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="tetR">
            <annotation>
              <celldesigner:alias>sa6</celldesigner:alias>
            </annotation>
          </modifierSpeciesReference>
          <modifierSpeciesReference species="p_LacI">
            <annotation>
              <celldesigner:alias>sa14</celldesigner:alias>
            </annotation>
          </modifierSpeciesReference>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> tetR </ci>
              <apply>
                <plus/>
                <ci> l </ci>
                <apply>
                  <divide/>
                  <apply>
                    <times/>
                    <ci> t_max </ci>
                    <apply>
                      <power/>
                      <ci> K_i </ci>
                      <ci> h </ci>
                    </apply>
                  </apply>
                  <apply>
                    <plus/>
                    <apply>
                      <power/>
                      <ci> K_i </ci>
                      <ci> h </ci>
                    </apply>
                    <apply>
                      <power/>
                      <ci> p_LacI </ci>
                      <ci> h </ci>
                    </apply>
                  </apply>
                </apply>
              </apply>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction fast="false" id="re3" metaid="metaid_0000028" name="ptetR degradation" reversible="false" >
        <annotation>
          <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
          <celldesigner:baseReactants>
            <celldesigner:baseReactant alias="sa2" species="p_tetR">
              <celldesigner:linkAnchor position="E"/>
            </celldesigner:baseReactant>
          </celldesigner:baseReactants>
          <celldesigner:baseProducts>
            <celldesigner:baseProduct alias="sa8" species="Bin">
              <celldesigner:linkAnchor position="WNW"/>
            </celldesigner:baseProduct>
          </celldesigner:baseProducts>
          <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
            <celldesigner:listOfLineDirection>
              <celldesigner:lineDirection index="0" value="unknown"/>
            </celldesigner:listOfLineDirection>
          </celldesigner:connectScheme>
          <celldesigner:line color="ff000000" width="1.0"/>
          <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
            <rdf:Description rdf:about="#metaid_0000028">
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                <rdf:Bag>
                  <rdf:li xmlns:ns0="http://www.w3.org/1999/02/22-rdf-syntax-ns#" ns0:resource="urn:miriam:obo.go:GO%3A0030163"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="p_tetR">
            <annotation>
              <celldesigner:alias>sa2</celldesigner:alias>
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          </speciesReference>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="Bin">
            <annotation>
              <celldesigner:alias>sa8</celldesigner:alias>
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          </speciesReference>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> k_dP </ci>
              <ci> p_tetR </ci>
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          </math>
        </kineticLaw>
      </reaction>
      <reaction fast="false" id="re4" metaid="metaid_0000029" name="mtetR degradation" reversible="false" >
        <annotation>
          <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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            <celldesigner:baseReactant alias="sa5" species="m_tetR">
              <celldesigner:linkAnchor position="E"/>
            </celldesigner:baseReactant>
          </celldesigner:baseReactants>
          <celldesigner:baseProducts>
            <celldesigner:baseProduct alias="sa9" species="Bin">
              <celldesigner:linkAnchor position="WNW"/>
            </celldesigner:baseProduct>
          </celldesigner:baseProducts>
          <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
            <celldesigner:listOfLineDirection>
              <celldesigner:lineDirection index="0" value="unknown"/>
            </celldesigner:listOfLineDirection>
          </celldesigner:connectScheme>
          <celldesigner:line color="ff000000" width="1.0"/>
          <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
            <rdf:Description rdf:about="#metaid_0000029">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li xmlns:ns0="http://www.w3.org/1999/02/22-rdf-syntax-ns#" ns0:resource="urn:miriam:obo.go:GO%3A0006401"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="m_tetR">
            <annotation>
              <celldesigner:alias>sa5</celldesigner:alias>
            </annotation>
          </speciesReference>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="Bin">
            <annotation>
              <celldesigner:alias>sa9</celldesigner:alias>
            </annotation>
          </speciesReference>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> k_dR </ci>
              <ci> m_tetR </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction fast="false" id="re5" metaid="metaid_0000030" name="LacI translation" reversible="false" >
        <annotation>
          <celldesigner:reactionType>TRANSLATION</celldesigner:reactionType>
          <celldesigner:baseReactants>
            <celldesigner:baseReactant alias="sa12" species="Source">
              <celldesigner:linkAnchor position="E"/>
            </celldesigner:baseReactant>
          </celldesigner:baseReactants>
          <celldesigner:baseProducts>
            <celldesigner:baseProduct alias="sa14" species="p_LacI">
              <celldesigner:linkAnchor position="W"/>
            </celldesigner:baseProduct>
          </celldesigner:baseProducts>
          <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
            <celldesigner:listOfLineDirection>
              <celldesigner:lineDirection index="0" value="unknown"/>
            </celldesigner:listOfLineDirection>
          </celldesigner:connectScheme>
          <celldesigner:line color="ff000000" width="1.0"/>
          <celldesigner:listOfModification>
            <celldesigner:modification aliases="sa13" modifiers="m_LacI" targetLineIndex="-1,6" type="TRIGGER">
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                <celldesigner:listOfLineDirection>
                  <celldesigner:lineDirection index="0" value="unknown"/>
                </celldesigner:listOfLineDirection>
              </celldesigner:connectScheme>
              <celldesigner:linkTarget alias="sa13" species="m_LacI">
                <celldesigner:linkAnchor position="NNE"/>
              </celldesigner:linkTarget>
              <celldesigner:line color="ff000000" width="1.0"/>
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          </celldesigner:listOfModification>
          <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
            <rdf:Description rdf:about="#metaid_0000030">
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                <rdf:Bag>
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              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="Source">
            <annotation>
              <celldesigner:alias>sa12</celldesigner:alias>
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          </speciesReference>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="p_LacI">
            <annotation>
              <celldesigner:alias>sa14</celldesigner:alias>
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          </speciesReference>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="m_LacI">
            <annotation>
              <celldesigner:alias>sa13</celldesigner:alias>
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          </modifierSpeciesReference>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> k_tl </ci>
              <ci> m_LacI </ci>
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          </math>
        </kineticLaw>
      </reaction>
      <reaction fast="false" id="re6" metaid="metaid_0000031" name="LacI transcription" reversible="false" >
        <annotation>
          <celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
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            <celldesigner:baseReactant alias="sa10" species="Source">
              <celldesigner:linkAnchor position="E"/>
            </celldesigner:baseReactant>
          </celldesigner:baseReactants>
          <celldesigner:baseProducts>
            <celldesigner:baseProduct alias="sa13" species="m_LacI">
              <celldesigner:linkAnchor position="W"/>
            </celldesigner:baseProduct>
          </celldesigner:baseProducts>
          <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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              <celldesigner:lineDirection index="0" value="unknown"/>
            </celldesigner:listOfLineDirection>
          </celldesigner:connectScheme>
          <celldesigner:line color="ff000000" width="1.0"/>
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            <celldesigner:modification aliases="sa11" modifiers="LacI" targetLineIndex="-1,3" type="TRIGGER">
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                <celldesigner:listOfLineDirection>
                  <celldesigner:lineDirection index="0" value="unknown"/>
                </celldesigner:listOfLineDirection>
              </celldesigner:connectScheme>
              <celldesigner:linkTarget alias="sa11" species="LacI">
                <celldesigner:linkAnchor position="N"/>
              </celldesigner:linkTarget>
              <celldesigner:line color="ff000000" width="1.0"/>
            </celldesigner:modification>
            <celldesigner:modification aliases="sa20" modifiers="p_cI" targetLineIndex="-1,7" type="INHIBITION">
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                <celldesigner:listOfLineDirection>
                  <celldesigner:lineDirection index="0" value="unknown"/>
                </celldesigner:listOfLineDirection>
              </celldesigner:connectScheme>
              <celldesigner:linkTarget alias="sa20" species="p_cI">
                <celldesigner:linkAnchor position="NW"/>
              </celldesigner:linkTarget>
              <celldesigner:line color="ff000000" width="1.0"/>
            </celldesigner:modification>
          </celldesigner:listOfModification>
          <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
            <rdf:Description rdf:about="#metaid_0000031">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li xmlns:ns0="http://www.w3.org/1999/02/22-rdf-syntax-ns#" ns0:resource="urn:miriam:obo.go:GO%3A0006402"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="Source">
            <annotation>
              <celldesigner:alias>sa10</celldesigner:alias>
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          </speciesReference>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="m_LacI">
            <annotation>
              <celldesigner:alias>sa13</celldesigner:alias>
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          </speciesReference>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="LacI">
            <annotation>
              <celldesigner:alias>sa11</celldesigner:alias>
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          </modifierSpeciesReference>
          <modifierSpeciesReference species="p_cI">
            <annotation>
              <celldesigner:alias>sa20</celldesigner:alias>
            </annotation>
          </modifierSpeciesReference>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> LacI </ci>
              <apply>
                <plus/>
                <ci> l </ci>
                <apply>
                  <divide/>
                  <apply>
                    <times/>
                    <ci> t_max </ci>
                    <apply>
                      <power/>
                      <ci> K_i </ci>
                      <ci> h </ci>
                    </apply>
                  </apply>
                  <apply>
                    <plus/>
                    <apply>
                      <power/>
                      <ci> K_i </ci>
                      <ci> h </ci>
                    </apply>
                    <apply>
                      <power/>
                      <ci> p_cI </ci>
                      <ci> h </ci>
                    </apply>
                  </apply>
                </apply>
              </apply>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction fast="false" id="re7" metaid="metaid_0000032" name="pLacI degradation" reversible="false" >
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          <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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            <celldesigner:baseReactant alias="sa14" species="p_LacI">
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            </celldesigner:baseReactant>
          </celldesigner:baseReactants>
          <celldesigner:baseProducts>
            <celldesigner:baseProduct alias="sa16" species="Bin">
              <celldesigner:linkAnchor position="W"/>
            </celldesigner:baseProduct>
          </celldesigner:baseProducts>
          <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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          </celldesigner:connectScheme>
          <celldesigner:line color="ff000000" width="1.0"/>
          <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
            <rdf:Description rdf:about="#metaid_0000032">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li xmlns:ns0="http://www.w3.org/1999/02/22-rdf-syntax-ns#" ns0:resource="urn:miriam:obo.go:GO%3A0030163"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="p_LacI">
            <annotation>
              <celldesigner:alias>sa14</celldesigner:alias>
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          </speciesReference>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="Bin">
            <annotation>
              <celldesigner:alias>sa16</celldesigner:alias>
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          </speciesReference>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> k_dP </ci>
              <ci> p_LacI </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction fast="false" id="re8" metaid="metaid_0000033" name="mLacI degradation" reversible="false" >
        <annotation>
          <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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            <celldesigner:baseReactant alias="sa13" species="m_LacI">
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            </celldesigner:baseReactant>
          </celldesigner:baseReactants>
          <celldesigner:baseProducts>
            <celldesigner:baseProduct alias="sa15" species="Bin">
              <celldesigner:linkAnchor position="WNW"/>
            </celldesigner:baseProduct>
          </celldesigner:baseProducts>
          <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
            <celldesigner:listOfLineDirection>
              <celldesigner:lineDirection index="0" value="unknown"/>
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          </celldesigner:connectScheme>
          <celldesigner:line color="ff000000" width="1.0"/>
          <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
            <rdf:Description rdf:about="#metaid_0000033">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li xmlns:ns0="http://www.w3.org/1999/02/22-rdf-syntax-ns#" ns0:resource="urn:miriam:obo.go:GO%3A0006401"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="m_LacI">
            <annotation>
              <celldesigner:alias>sa13</celldesigner:alias>
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          </speciesReference>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="Bin">
            <annotation>
              <celldesigner:alias>sa15</celldesigner:alias>
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          </speciesReference>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> k_dR </ci>
              <ci> m_LacI </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction fast="false" id="re9" metaid="metaid_0000034" name="cI translation" reversible="false" >
        <annotation>
          <celldesigner:reactionType>TRANSLATION</celldesigner:reactionType>
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            <celldesigner:baseReactant alias="sa18" species="Source">
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          </celldesigner:baseReactants>
          <celldesigner:baseProducts>
            <celldesigner:baseProduct alias="sa20" species="p_cI">
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          </celldesigner:baseProducts>
          <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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          <celldesigner:line color="ff000000" width="1.0"/>
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            <celldesigner:modification aliases="sa17" modifiers="m_cI" targetLineIndex="-1,6" type="TRIGGER">
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          <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
            <rdf:Description rdf:about="#metaid_0000034">
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                <rdf:Bag>
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              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="Source">
            <annotation>
              <celldesigner:alias>sa18</celldesigner:alias>
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          </speciesReference>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="p_cI">
            <annotation>
              <celldesigner:alias>sa20</celldesigner:alias>
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          </speciesReference>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="m_cI">
            <annotation>
              <celldesigner:alias>sa17</celldesigner:alias>
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          </modifierSpeciesReference>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> k_tl </ci>
              <ci> m_cI </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction fast="false" id="re10" metaid="metaid_0000035" name="cI transcription" reversible="false" >
        <annotation>
          <celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
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            <celldesigner:baseReactant alias="sa19" species="Source">
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          </celldesigner:baseReactants>
          <celldesigner:baseProducts>
            <celldesigner:baseProduct alias="sa17" species="m_cI">
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          </celldesigner:baseProducts>
          <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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          <celldesigner:line color="ff000000" width="1.0"/>
          <celldesigner:listOfModification>
            <celldesigner:modification aliases="sa21" modifiers="cI" targetLineIndex="-1,3" type="TRIGGER">
              <celldesigner:connectScheme connectPolicy="direct">
                <celldesigner:listOfLineDirection>
                  <celldesigner:lineDirection index="0" value="unknown"/>
                </celldesigner:listOfLineDirection>
              </celldesigner:connectScheme>
              <celldesigner:linkTarget alias="sa21" species="cI">
                <celldesigner:linkAnchor position="N"/>
              </celldesigner:linkTarget>
              <celldesigner:line color="ff000000" width="1.0"/>
            </celldesigner:modification>
            <celldesigner:modification aliases="sa2" editPoints="-0.2084264482699656,-0.20368673634116752 0.35473461610225465,-0.7881517986087362 0.9934900579518706,-0.17850639545038682" modifiers="p_tetR" targetLineIndex="-1,7" type="INHIBITION">
              <celldesigner:connectScheme connectPolicy="direct">
                <celldesigner:listOfLineDirection>
                  <celldesigner:lineDirection index="0" value="vertical"/>
                  <celldesigner:lineDirection index="1" value="unknown"/>
                  <celldesigner:lineDirection index="2" value="unknown"/>
                  <celldesigner:lineDirection index="3" value="unknown"/>
                </celldesigner:listOfLineDirection>
              </celldesigner:connectScheme>
              <celldesigner:linkTarget alias="sa2" species="p_tetR">
                <celldesigner:linkAnchor position="NE"/>
              </celldesigner:linkTarget>
              <celldesigner:line color="ff000000" width="1.0"/>
            </celldesigner:modification>
          </celldesigner:listOfModification>
          <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
            <rdf:Description rdf:about="#metaid_0000035">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li xmlns:ns0="http://www.w3.org/1999/02/22-rdf-syntax-ns#" ns0:resource="urn:miriam:obo.go:GO%3A0006402"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="Source">
            <annotation>
              <celldesigner:alias>sa19</celldesigner:alias>
            </annotation>
          </speciesReference>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="m_cI">
            <annotation>
              <celldesigner:alias>sa17</celldesigner:alias>
            </annotation>
          </speciesReference>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="cI">
            <annotation>
              <celldesigner:alias>sa21</celldesigner:alias>
            </annotation>
          </modifierSpeciesReference>
          <modifierSpeciesReference species="p_tetR">
            <annotation>
              <celldesigner:alias>sa2</celldesigner:alias>
            </annotation>
          </modifierSpeciesReference>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> cI </ci>
              <apply>
                <plus/>
                <ci> l </ci>
                <apply>
                  <divide/>
                  <apply>
                    <times/>
                    <ci> t_max </ci>
                    <apply>
                      <power/>
                      <ci> K_i </ci>
                      <ci> h </ci>
                    </apply>
                  </apply>
                  <apply>
                    <plus/>
                    <apply>
                      <power/>
                      <ci> K_i </ci>
                      <ci> h </ci>
                    </apply>
                    <apply>
                      <power/>
                      <ci> p_tetR </ci>
                      <ci> h </ci>
                    </apply>
                  </apply>
                </apply>
              </apply>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction fast="false" id="re11" metaid="metaid_0000036" name="p_cI degradation" reversible="false" >
        <annotation>
          <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
          <celldesigner:baseReactants>
            <celldesigner:baseReactant alias="sa20" species="p_cI">
              <celldesigner:linkAnchor position="E"/>
            </celldesigner:baseReactant>
          </celldesigner:baseReactants>
          <celldesigner:baseProducts>
            <celldesigner:baseProduct alias="sa23" species="Bin">
              <celldesigner:linkAnchor position="W"/>
            </celldesigner:baseProduct>
          </celldesigner:baseProducts>
          <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
            <celldesigner:listOfLineDirection>
              <celldesigner:lineDirection index="0" value="unknown"/>
            </celldesigner:listOfLineDirection>
          </celldesigner:connectScheme>
          <celldesigner:line color="ff000000" width="1.0"/>
          <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
            <rdf:Description rdf:about="#metaid_0000036">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li xmlns:ns0="http://www.w3.org/1999/02/22-rdf-syntax-ns#" ns0:resource="urn:miriam:obo.go:GO%3A0030163"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="p_cI">
            <annotation>
              <celldesigner:alias>sa20</celldesigner:alias>
            </annotation>
          </speciesReference>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="Bin">
            <annotation>
              <celldesigner:alias>sa23</celldesigner:alias>
            </annotation>
          </speciesReference>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> k_dP </ci>
              <ci> p_cI </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction fast="false" id="re12" metaid="metaid_0000037" name="m_cI degradation" reversible="false" >
        <annotation>
          <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
          <celldesigner:baseReactants>
            <celldesigner:baseReactant alias="sa17" species="m_cI">
              <celldesigner:linkAnchor position="E"/>
            </celldesigner:baseReactant>
          </celldesigner:baseReactants>
          <celldesigner:baseProducts>
            <celldesigner:baseProduct alias="sa22" species="Bin">
              <celldesigner:linkAnchor position="WNW"/>
            </celldesigner:baseProduct>
          </celldesigner:baseProducts>
          <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
            <celldesigner:listOfLineDirection>
              <celldesigner:lineDirection index="0" value="unknown"/>
            </celldesigner:listOfLineDirection>
          </celldesigner:connectScheme>
          <celldesigner:line color="ff000000" width="1.0"/>
          <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
            <rdf:Description rdf:about="#metaid_0000037">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li xmlns:ns0="http://www.w3.org/1999/02/22-rdf-syntax-ns#" ns0:resource="urn:miriam:obo.go:GO%3A0006401"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="m_cI">
            <annotation>
              <celldesigner:alias>sa17</celldesigner:alias>
            </annotation>
          </speciesReference>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="Bin">
            <annotation>
              <celldesigner:alias>sa22</celldesigner:alias>
            </annotation>
          </speciesReference>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> k_dR </ci>
              <ci> m_cI </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
    </listOfReactions>
  </model>
</sbml>
