MathsNet: Research Student Directory

Name Tilunaite, Agne
Group Mathematical Medicine and Biology
Room C32, Math Sci
Telephone +44 (0) 115 95 13858 [direct dial]
Thesis Title Modelling of intracellular calcium dynamics
Thesis Abstract A major challenge in physiology is to understand the rules governing cell signalling pathways that control cellular behaviour. This project aims to provide quantitative insights into cellular decision making by using techniques from computational cell biology and mathematical cell physiology as well as ideas and concepts from dynamical systems theory, random processes and information processing. In particular, we will focus on the dynamics of intracellular calcium in response to different agonists and different agonists concentrations provided by Tom Bellamy's lab. Our working hypothesis is that cells distinguish between different stimulations by carefully tuning the spatio-temporal patterns of intracellular calcium oscillations. We will address this question by testing the dynamics of different existing models of the inositol-1,4,5-trisphosphate (IP3) receptor in a spatially extended cell environment, which may also require the construction of a novel IP3 receptor model. In addition, we will pay specific attention to the spatial arrangement of key components of the calcium signalling toolbox. A major challenge of the project will be the construction of cellular response functions to time varying stimulation, both deterministic and stochastic.
School contact information School of Mathematical Sciences
University of Nottingham
University Park
Nottingham, NG7 2RD
Tel: +44 (0) 115 951 4949
Fax: +44 (0) 115 951 4951