MathsNet: Research Student Directory

Name den Ouden, Ellen
Group Mathematical Medicine and Biology
Room C11, Math Sci
Telephone +44 (0) 115 95 14925 [direct dial]
Thesis Title Biomechanical model of airway structure and function in asthma
Thesis Abstract Asthma is a chronic inflammatory disease characterised by airway hyper-responsiveness which leads to airway smooth muscle contraction and airway bronchoconstriction. The aim of this project is to develop a multiscale biomechanical model of the airway, coupling cellular level force generation to a model of a collapsible airway accounting for anisotropic tissue properties and internal flow. Previous models of single airways neglecting flow have highlighted important mechanisms under which bronchodilation is possible; here we will investigate deep-inspiration driven bronchodilation using the proposed flow-structure interaction models. Further to this we will investigate how these mechanisms underpin structure-function relationships of airways in a branching network for which significant model reduction of the multiscale model will be required.
School contact information School of Mathematical Sciences
University of Nottingham
University Park
Nottingham, NG7 2RD
Tel: +44 (0) 115 951 4949
Fax: +44 (0) 115 951 4951