MathsNet: Research Student Directory

Name den Ouden, Ellen
Group Mathematical Medicine and Biology
Room C11, Math Sci
Telephone +44 (0) 115 95 14925 [direct dial]
Email
Thesis Title Biomechanical model of airway structure and function in asthma
Thesis Abstract Asthma is a chronic inflammatory disease characterised by airway hyper-responsiveness which leads to airway smooth muscle contraction and airway bronchoconstriction. The aim of this project is to develop a multiscale biomechanical model of the airway, coupling cellular level force generation to a model of a collapsible airway accounting for anisotropic tissue properties and internal flow. Previous models of single airways neglecting flow have highlighted important mechanisms under which bronchodilation is possible; here we will investigate deep-inspiration driven bronchodilation using the proposed flow-structure interaction models. Further to this we will investigate how these mechanisms underpin structure-function relationships of airways in a branching network for which significant model reduction of the multiscale model will be required.
School contact information School of Mathematical Sciences
University of Nottingham
University Park
Nottingham, NG7 2RD
UK
Tel: +44 (0) 115 951 4949
Fax: +44 (0) 115 951 4951