MathsNet: Research Student Directory

Name Pybus, Hannah Jane
Group Mathematical Medicine and Biology
Room A14, Maths
Telephone +44 (0) 115 [direct dial]
Email
Thesis Title Bottom up development of multi-scale models of airway remodelling in asthma: from cell to tissue
Thesis Abstract Asthma is a highly prevalent disease characterised by airway hyper-responsiveness and remodelling. Until recently, airway remodelling has been predominantly associated with chronic inflammation acting over long timescales. Current experimental evidence suggests that bronchoconstriction, as a result of airway smooth muscle cell (ASMc) contraction, activates transforming growth factor b (TGF-b), a regulatory cytokine implicated in excessive inflammatory injury repair responses. This may further stimulate ASMc contraction and growth over shorter timescales. The effects of cell-mediated TGF-b activation, during tidal breathing, continue to be debated. Coupling subcellular mechanotransduction signalling pathways to biomechanical models of ASMc and extracellular matrix (ECM) proteins, we aim to develop a tissue level biomechanical description of the resultant growth in ASM. Informed by ongoing lung slice experiments undertaken in the Division of Respiratory Medicine, the primary focus is to produce a mathematical model closely resembling the experimentally observed behaviour, with the ultimate intention of providing insight into mechanisms that may operate in the intact asthmatic airway in vivo.
School contact information School of Mathematical Sciences
University of Nottingham
University Park
Nottingham, NG7 2RD
UK
Tel: +44 (0) 115 951 4949
Fax: +44 (0) 115 951 4951