MathsNet: Research Student Directory

Name Veasy, Joshua D
Group Mathematical Medicine and Biology
Room C32, Math Sci
Telephone +44 (0) 115 95 13858 [direct dial]
Thesis Title Cardiac calcium signalling
Thesis Abstract Cardiac alternans are cyclic changes in certain behaviours of the heart; for example strength of the heartbeat. One of the underlying causes of cardiac alternans, are changes to the oscillating patterns of the calcium levels within the small chambers of the heart. The pattern most suspected for these cardiac alternans are themselves described as calcium alternans. Since calcium acts as a signalling molecule, looking at the conditions under which these alternans occur may help us to understand how such behaviour may be linked to certain heart conditions. Within this project we shall study the effects of certain key parameters within the cellular system that drives these alternans, as well as study the effects due to the strength of coupling between certain cell regions or entire cells. We shall also take a look at how changing the shape of the action potential, the driving force behind these systems, can have an effect on the oscillating behaviour of cellular calcium levels. By doing such research we can hope to understand further the underlying causes of cardiac alternans, which is linked to conditions such as cardiac arrhythmia, and thus aid the effort to treat and prevent such conditions.
School contact information School of Mathematical Sciences
University of Nottingham
University Park
Nottingham, NG7 2RD
Tel: +44 (0) 115 951 4949
Fax: +44 (0) 115 951 4951