MathsNet: Research Student Directory

Name Coleman, Matthew
Group Mathematical Medicine and Biology
Room C18, Math Sci
Telephone +44 (0) 115 95 14961 [direct dial]
Thesis Title Flux Balance Techniques for Modelling Metabolic Networks and Comparison with Kinetic Models
Thesis Abstract Metabolic engineering is the process by which we modify the metabolism of living cells in order to change or improve the metabolic behaviour of the organism. This can be done to increase yields of products such as biofuels, or engineer resistance to conditions that would normally be fatal to the organism. Mathematical models of metabolism are useful tools with which to guide this metabolic engineering, highlighting potential targets to provide the best results. We wish to analyze the metabolism of living organisms using a variety of different modelling methods, such as ordinary differential equations and CoBRA methods. We compare the results of the different modelling methods to highlight their differences and individual strengths across a variety of metabolic networks.
School contact information School of Mathematical Sciences
University of Nottingham
University Park
Nottingham, NG7 2RD
Tel: +44 (0) 115 951 4949
Fax: +44 (0) 115 951 4951